DESCRIPTION Gene Name Synonym HAVCR2, TIM3, TIMD3, FLJ14428, KIM3, T-cell immunoglobulin mucin family member 3, TIM-3, CD366 Species Mouse Accession Q8VIM0 Source HEK293 cells SPECIFICATIONS Amino acid sequence Arg20-Ala193 is expressed with a 10×His tag at the C terminus Molecular Weight 19.3 kDa（The protein migrates as 20-40 kDa under reducing condition (SDS-PAGE) due to glycosylation） Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. Data SDS-PAGE Bioactivity Testing in progress Recombinant Mouse TIM3 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 30-50 kDa. （产品包装升级中，以实物为准。 ） 仅供科研用途，不可用于临床诊断！