DESCRIPTION Gene Name Synonym CD4 Species Mouse Accession P06332 Source HEK293 cells SPECIFICATIONS Amino acid sequence Lys27-Thr394 is expressed with a 10×His tag at the N terminus Molecular Weight 40 kDa Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND CD4 is a monomeric glycoprotein expressed on approximately 60% of peripheral blood T lymphocytes. CD4 (T4), a glycoprotein expressed largely on the surface of cells in the immune system, serves as the receptor for the human immunodeficiency virus, HIV. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen-presenting cell. The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR and also subserves as the receptor for the human immunodeficiency viruses. Data SDS-PAGE Bioactivity Active Recombinant Mouse CD4 Protein was determined by SDS-PAGE with Coomassie Blue, showing band at 42-55 kDa. Immobilized Mouse CD4, His Tag at 3 μg/mL (100 μL/well) can bind Anti-CD4 with a linear range of 0.06-0.94 ng/mL. 仅供科研用途，不可用于临床诊断！