DESCRIPTION Gene Name Synonym CD365, TIM1; TIM, TIMD1, TIMD-1, HAVCR1, HAVCR-1, HAVCR, KIM1, KIM-1 Species Mouse Accession Q5QNS5 Source HEK293 cells SPECIFICATIONS Amino acid sequence Tyr22-Gly237 is expressed with a 10×His tag at the C terminus Molecular Weight 27.6 kDa Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Hepatitis A virus cellular receptor 1 is also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. Data SDS-PAGE Bioactivity Testing in progress. Recombinant Mouse CD365 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 60-100 kDa. 仅供科研用途，不可用于临床诊断！