DESCRIPTION Gene Name Synonym IL21R, CD360, NILR Species Human Accession Q9HBE5 Source HEK293 cells SPECIFICATIONS Amino acid sequence Cys20-Glu232 is expressed with a 10×His tag at the C terminus Molecular Weight 28.5 kDa Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Interleukin-21 receptor (IL21R) is also known as CD antigen CD360, Novel interleukin receptor (NILR), is a receptor for interleukin-21 and belongs to the type I cytokine receptor family or type 4 subfamily. IL21R contains two fibronectin type-III domains. IL21R is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen. IL21R transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. CD360 is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. The CD360 is widely distributed on lymphohematopoietic cells and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells. Data SDS-PAGE Bioactivity Testing in progress. Recombinant Human CD360 Protein was determined by SDS-PAGE with Coomassie Blue. 仅供科研用途，不可用于临床诊断！