DESCRIPTION Gene Name Synonym TREM1, CD354, TREM-1 Species Human Accession Q9NP99 Source HEK293 cells SPECIFICATIONS Amino acid sequence Ala21-Asn205 is expressed with a 10×His tag at the C terminus Molecular Weight 20.2 kDa Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND CD354, Triggering Receptor of Myeloid Cells-1(TREM-1), is a potent amplifier of myeloid immune responses. CD354 is a type I transmembrane protein with a single Ig-like domain, and is selectively expressed on blood neutrophils and a subset of monocytes.TREM-1 potently amplified the function of TLR and Nod-like receptors (NLR) which resulted in enhanced cytokine production. TREM-1 was first described as a costimulatory receptor on myeloid cells. Antagonizing TREM-1 with antibodies, fusion proteins, or inhibitory peptides reduces inflammation in experimental arthritis and colitis models.TREM-1 mRNA and protein were elevated in inflammatory bowel disease, experimental colitis, inflammatory arthritis, and other noninfectious inflammatory diseases.TREM1 performs a critical function in immune responses involved in host defense against microbial challenges, and is suggested to be a potential therapeutic target for septic shock. Data SDS-PAGE Bioactivity Testing in progress Recombinant Human CD354 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 35-60 kDa. 仅供科研用途，不可用于临床诊断！