Product Information Protein full name Histone deacetylase 6 (HD6) (EC 3.5.1.98) Gene Id 10013 Immunogen Synthesized peptide derived from human HDAC6 Uniprot ID Q9UBN7 Source Mouse/IgG1, Kappa Concentration 1 mg/ml Purity The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. Applications IHC/IF Human 1: 200-1: 500 kindey Background Histone deacetylases(HDAC) are a class of enzymes that remove the acetyl groups from the lysine residues leading to the formation of a condensed and transcriptionally silenced chromatin. At least 4 classes of HDAC were identified. HDAC6 is a member of the class II mammalian histone deacetylases. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation. Images Immunohistochemistry analysis of paraffin embedded human kindey using HDAC6 (GB14096) at dilution of 1: 200 Storage Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. NOTE: 1.This product is intended for research only. 2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （ G2025 ）.