Product Information Description Beclin 1 rabbit polyclonal Protein full name Beclin-1 Synonyms BECN1,ATG6,VPS30,beclin1,beclin-1, GT197 Immunogen Recombinant protein corresponding to human beclin 1 Isotype IgG Purity Affinity purification Predicted MW. 52 kDa Observed MW. 60 kDa Uniprot ID Q14457 , Q91XJ1, O88597 Applications Applications Species Dilution Positive Tissue WB Human, Mouse, Rat 1:1000 brain Background Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Images All lanes are rat brain tissue lysate Western blot analysis of Beclin 1 (GB13228-1) at dilution of 1:1000. Storage Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE: 1.This product is intended for research only. 2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （ G2025 ）.