Product Information Description Beclin 1 rabbit polyclonal Protein full name Beclin-1 Synonyms BECN1, ATG6, VPS30, beclin1, beclin 1 Immunogen KLH conjugated Synthetic peptide corresponding to Human Beclin 1 Isotype IgG Purity Affinity purification Predicted MW. 50 kDa Observed MW. 50 kDa Uniprot ID O88597, Q91XJ1 Applications Applications Species Dilution Positive Tissue WB Mouse, Rat 1:500-1:1000 heart, liver, brain Background Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. Images Western blot analysis of Beclin 1 (GB13228-2) at dilution of 1:1000. Lane 1: Hela cell lysate Lane 2: A549 cell lysate Lane 3: MCF-7 cell lysate Lane 4: Mouse heart tissue lysate Lane 5: Mouse liver tissue lysate Lane 6: Mouse brain tissue lysate Lane 7: Rat heart tissue lysate Lane 8: Rat liver tissue lysate Lane 9: Rat brain tissue lysate Storage Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE: 1.This product is intended for research only. 2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （ G2025 ）.