DESCRIPTION Gene Name Synonym C7 , IFI10 , INP10 , IP-10 , crg-2 , mob-1 , SCYB10 , gIP-10 , CXCL10 Species Mouse Accession P17515 Source HEK293 cells SPECIFICATIONS Amino acid sequence Ile22-Pro98 is expressed with a 10×His tag at the C terminus Molecular Weight 8.7 kDa Purity >95.0% as determined by SDS-PAGE Endotoxin <5 EU mg -1 Formulation Lyophilized from sterile PBS, pH 7.4.Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND C-X-C Motif Chemokine Ligand 10 (CXCL10) is a pro-inflammatory chemokine secreted by a wide spectrum of cells. It is involved in multiple mechanisms and reported to have pleiotropic effects, including immune cell migration and attraction to inflammation sites, angiogenesis, and cancer cell growth. CXCL10 is produced by pancreatic islet cells upon inflammatory stress and is specifically recognized by C-X-C Motif Chemokine Receptor 3 (CXCR3) which is expressed by activated T-lymphocytes and other immune cells. Data SDS-PAGE Bioactivity Recombinant Mouse CXCL10 Protein was determined by SDS-PAGE with Coomassie Blue. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC-T1). The ED50 for this effect is typically 0.05-0.1 μg/mL. 仅供科研用途，不可用于临床诊断！