DESCRIPTION Gene Name Synonym CALCA, calcitonin related polypeptide alpha, CGRP, CGRP1, CT, katacalcin, KC, Procalcitonin, PCT Species Human A ccession P01258 Source E.coli SPECIFICATIONS Amino acid sequence E.coli-derived Human Procalcitonin protein, Ala26-Asn141. Molecular Weight Approximately 13.0 kDa. Purity >95.0% as determined by SDS-PAGE. Endotoxin <1.0 EU/μg of the protein by the LAL method. Formulation Lyophilized from sterile Tris-Hcl, pH 8.0. Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Reconstitution Dissolved in sterile water, it is recommended to add 0.1% HSA or BSA for long-term preservation. STORAGE Stability and Storage 12 months from date of receipt at -20°C to -70°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for almost 6 months (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage. BACKGROUND Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus, which is subsequently cleaved into three parts : a 57 aa pro-region, a 32 aa Calcitonin peptide and a 21 aa Katacalcin peptide. PCT is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. PCT is considered to be one of the earliest and most specific markers of sepsis. Data SDS-PAGE Bioactivity Testing in progress Recombinant Human PCT Protein was determined by SDS-PAGE with Coomassie Blue. （产品包装升级中，以实物为准。 ） 仅供科研用途，不可用于临床诊断！