产品信息

蛋白质全称	脂肪酸2-羟化酶
别名	FA2H, FAAH, FAH1, fatty acid 2 hydroxylase, Fatty acid alpha hydroxylase, FAXDC1, SCS7
Uniprot ID	Q5MPP0
免疫原	KLH偶联的小鼠FA2H合成肽
抗体亚型	IgG
纯化方式	亲和纯化
亚细胞定位	内质网, 膜, 微粒体

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应用

应用	物种	稀释	阳性样品
IHC/IF 免疫组织化学/免疫荧光	人	1: 300-1: 900	结肠

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背景

Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis . FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids . Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath . Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis .

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图像

IHC检测FA2H蛋白(货号 GB114704). 样品: 人结肠, 4%多聚甲醛 (货号G1101) 固定12-24小时. 抗原修复: 柠檬酸抗原修复液(干粉, pH 6.0) (G1201), 98℃, 20分钟. —抗: 1: 300稀释, 4℃ 孵育过夜. 二抗: HRP标记山羊抗兔IgG (H+L) (货号GB23303), 1: 200稀释, 室温孵育1小时.

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储存

储存条件	在-20℃下储存一年, 避免反复冻融.
储存缓冲液	含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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注意:

1.本产品仅供研究使用.

2.建议用一抗稀释液(G2025)稀释本产品.