Anti-Myeloperoxidase Mouse mAb
- 50 μL
Product Information
Protein full name | Myeloperoxidase(MPO) |
Gene Id | 4353 |
Immunogen | Synthesized peptide derived from human Myeloperoxidase(MPO) |
Uniprot ID | P05164 |
Source | Mouse/IgG2a, Kappa |
Concentration | 1 mg/ml |
Purity | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Applications
IHC/IF | Human | 1: 200-1: 500 | tonsil |
Background
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities . The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains . The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit . Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. This antibody is specific to MPO.
Images
| Immunohistochemistry analysis of paraffin embedded human tonsil using Myeloperoxidase (GB14115) at dilution of 1: 200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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