Anti-pan Cadherin Mouse mAb
- 50 μL
Product Information
Protein full name | Cadherin-1 |
Immunogen | Synthesized peptide derived from human cadherin pan |
Uniprot ID | P12830/P19022/P22223/P55283 |
Source | Mouse/IgG1, Kappa |
Concentration | 1 mg/ml |
Purity | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Applications
IHC/IF | Human | 1: 200-1: 500 | pancreas |
Background
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice. E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin).
Images
| Immunohistochemistry analysis of paraffin embedded human pancreas using Pan-cadherin (GB14014) at dilution of 1: 200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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