RANKL
- 50 μL
Product Information
Description | RANKL rabbit polyclonal |
Protein full name | tumor necrosis factor (ligand) superfamily, member 11 |
Synonyms | CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE |
Immunogen | RANKL fusion protein Ag19975 |
Isotype | IgG |
Purity | Antigen affinity purification |
Subcellular location | Cytoplasm, Secreted, Cell membrane |
Predicted MW. | 35 kDa |
Observed MW. | |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | 1: 200 -1: 1000 |
Background
TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL is a polypeptide of 217 amino acids that exerts its biological activity both in a transmembrane form of about 40-45 kDa and in soluble one of 31 kDa. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|