opn
- 50 μL
Product Information
Description | Osteopontin rabbit polyclonal |
Protein full name | secreted phosphoprotein 1 |
Synonyms | BNSP, Bone sialoprotein 1, BSPI, ETA 1, Nephropontin, OPN, Osteopontin, secreted phosphoprotein 1, SPP 1, SPP1, Urinary stone protein, Uropontin |
Immunogen | Osteopontin fusion protein Ag19216 |
Isotype | IgG |
Purity | Antigen affinity purification |
Subcellular location | |
Predicted MW. | 31 kDa |
Observed MW. | 70 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive |
WB | Human, Mouse, Rat | 1:1000 -1: 4000 | stomach cancer, colon cancer |
Background
Osteopontin (OPN), also known as SPP1, is a secreted glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. Originally isolated from bone, OPN has been found in kidney, vascular s, biological fluids, and various tumor s. OPN can interact with CD44 and integrins and regulate diverse biological processes. It has a multifaceted role in bone development and remodeling, and is also involved in the inflammatory and immune response, oncogenesis and cancer progression. The very acidic nature of OPN, as well as the presence of variable posttranslational modifications, has led to anomalous migration in SDS-polyacrylamide gels and therefore to reports of different molecular weights for OPN.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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