Product Information Protein full name DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS-alpha 160 kDa subunit) (p160) Gene Id 2956 Immunogen Synthesized peptide derived from human MutS Protein Homolog 6(MSH6) Uniprot ID P52701 Source Mouse/IgG1, Kappa Concentration 1 mg/ml Purity The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. Applications IHC/IF Human 1: 200-1: 500 colon carcinoma Background mutS homolog 6(MSH6) Homo sapiens This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013], Images Immunohistochemistry analysis of paraffin embedded human colon carcinoma using MSH6 (GB14109) at dilution of 1: 200 Storage Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. NOTE: 1.This product is intended for research only. 2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （ G2025 ）.