LC3
- 50 μL
Product Information
| Description | LC3A/B rabbit polyclonal |
| Protein full name | Microtubule-associated proteins 1A/1B light chain 3 |
| Synonyms | LC3, LC3A, LC3A/B, LC3B, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A, MAP1LC3A/B, MAP1LC3B |
| Immunogen | LC3 fusion protein Ag6144 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Cytoskeleton |
| Uniprot ID | Q9GZQ8, Q9H492, Q62625, Q6XVN8, Q9CQV6, Q91VR7 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Mouse, Rat | 1:300-1:1200 | brain, lung |
Background
LC3, also known as microtubule-associated protein 1 light chain 3 (MAP1LC3), is a mammalian homolog of the yeast Atg8p (autophagy-related 8 protein) that is involved in autophagy process. Three isoforms of LC3 exist as LC3A,LC3B, and LC3C. LC3 is first synthesized as pro-LC3, and undergoes C-terminal cleavage to yield a cytosolic precursor known as LC3-I. During autophagy LC3-I is subsequently conjugated to PE lipid as lipidated form: LC3-II. The lipidated form migrates faster on SDS-PAGE gel. The increased the level of LC3-II has been widely used as autophagy marker. This antibody recognizes both LC3-I and LC3-II.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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