Anti-Beclin 1 Rabbit pAb
- 50 μL
Product Information
| Description | Beclin 1 rabbit polyclonal |
| Protein full name |
Beclin-1 |
|
Synonyms |
BECN1,ATG6,VPS30,beclin1,beclin-1, GT197 |
| Immunogen |
Recombinant protein corresponding to human beclin 1 |
| Isotype | IgG |
| Purity | Affinity purification |
|
Predicted MW. |
52 kDa |
|
Observed MW. |
60 kDa |
| Uniprot ID |
Q14457, Q91XJ1, O88597 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1:1000 | brain |
Background
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer.
Images
 |
All lanes are rat brain tissue lysate Western blot analysis of Beclin 1 (YB13239-1) at dilution of 1:1000. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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