Anti-Beclin 1 Rabbit pAb
- 50 μL
Product Information
| Description |
Beclin 1 rabbit polyclonal |
| Protein full name |
Beclin-1 |
|
Synonyms |
BECN1, ATG6, VPS30, beclin1, beclin 1 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Human Beclin 1 |
| Isotype | IgG |
| Purity | Affinity purification |
|
Predicted MW. |
50 kDa |
|
Observed MW. |
50 kDa |
| Uniprot ID |
O88597, Q91XJ1 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1:500-1:1000 | heart, liver, brain |
Background
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.
Images
 |
Western blot analysis of Beclin 1 (YB13239-2) at dilution of 1:1000. Lane 1: Hela cell lysate Lane 2: A549 cell lysate Lane 3: MCF-7 cell lysate Lane 4: Mouse heart tissue lysate Lane 5: Mouse liver tissue lysate Lane 6: Mouse brain tissue lysate Lane 7: Rat heart tissue lysate Lane 8: Rat liver tissue lysate Lane 9: Rat brain tissue lysate
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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