产品信息

蛋白质全称	活性调节细胞骨架相关蛋白
别名	ARC, ARC/ARG3.1, Arg3.1, KIAA0278
Uniprot ID	Q7LC44
免疫原	KLH偶联的人ARC合成肽
抗体亚型	IgG
预测分子量./观测分子量.	45 kDa / 45 kDa
纯化方式	亲和纯化

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应用

应用	物种	稀释	阳性样品
WB 免疫印迹	人	1: 300-1: 400	YH-SY5Y细胞

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背景

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system.ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation.ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons.Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (YTP) and depression (LTD) and for the formation of long-term memory.

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图像

WB检测Arc蛋白(货号 YB115441). 样品: 经RIPA裂解液(货号Y2013)处理的蛋白质. 封闭: 封闭: 3%脱脂牛奶(货号YC310012)溶于TBST溶液, 室温孵育1小时. —抗: 1: 400稀释, 4℃ 孵育过夜. 二抗: HRP标记山羊抗兔IgG (H+L) (货号YB23314), 1: 5000稀释, 室温孵育1小时.

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储存

储存条件	在-20℃下储存一年, 避免反复冻融.
储存缓冲液	含0.15% ProClin300防腐剂, 100 μg/mL牛血清白蛋白和50%甘油的磷酸盐缓冲液.

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注意:

1.本产品仅供研究使用.

2.建议用一抗稀释液(Y2036)稀释本产品.