Anti-TIMP2 Rabbit pAb
- 100 μL
Product Information
Description | TIMP2 rabbit polyclonal |
Protein full name | Metalloproteinase inhibitor 2 |
Synonyms | TIMP2, CSC-21K, DDC8, TIMP metallopeptidase inhibitor 2 |
Immunogen | Recombinant protein corresponding to Mouse TIMP2 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | secreted |
Uniprot ID |
Applications
applications | species | dilution | Positive tissue |
IHC | Mouse, Rat | 1:700-1:1000 | testis, brain |
| IF | Mouse, Rat | 1:1000-1:2000 | testis, brain |
Background
TIMP2 encoded by Timp2 gene are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against
metalloproteinases, it has a unique role among TIMP family members in
its ability to directly suppress the proliferation of endothelial cells, which
may be critical to the maintenance of tissue homeostasis by suppressing
the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the
extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF. TIMP2 also plays an important role in hippocampal
function and cognitive function.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse testis using TIMP2 (YB11534) at dilution of 1:2000. |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using TIMP2 (YB11534) at dilution of 1:1400 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using TIMP2 (YB11534) at dilution of 1:1400 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|
| 货号 | 名称 | 规格 | 价格 | 操作 |
|---|
