ERK1/2
- 50 μL
Product Information
| Description | ERK1/2 rabbit polyclonal |
| Protein full name | ERK1/2 |
| Synonyms | Mitogen-activated protein kinase 3, MAP kinase 3,MAPK 3,ERT2, Extracellular signal-regulated kinase 1, ERK-1,Insulin-stimulated MAP2 kinase,MAP kinase isoform p44, p44-MAPK,Microtubule-associated protein 2 kinase,p44-ERK1,MAPK3,ERK1,PRKM3 |
| Immunogen | Synthetic peptide, corresponding to amino acids 320-370 of Human ERK1 |
| Isotype | IgG |
| Purity | Affinity purification |
| Subcellular location | Nucleus |
| Uniprot ID | P27361, P28482 |
Applications
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human, Mouse, Rat | 1: 50-1: 200 | eye, hepatoma, cervix, lymph |
Background
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.
Images
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （Y2036）.
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